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A prospective study obtaining breast measurements in a sample of Mexican female volunteers of the Plastic and Reconstructive Surgery department of the Hospital Central Sur de Alta Especialidad ( HCSAE) was performed. Rose, A. S. et al. NGL viewer: web-based molecular graphics for large complexes. Bioinformatics 34, 3755–3758 (2018). The sample was subdivided by decade of age in 4 groups: 3 rd decade, 4 th decade, 5 th decade > 6 th decade of life. And taking into consideration that breast size increases by 20 cc for every kg above the ideal body weight (BMI: 18.5 - 24.9 Kg/m 2), groups were also subdivided by BMI. Demographic information collected included: age, heigh, weight, BMI (Kg/m 2). She added: “I just think big boobs are really inconvenient, and you will see this week why I need a bra.”

This study evaluates the mean values of breast anthropometric measurements in a sample of Healthy Mexican Female volunteers, with the objective of establishing reference values for our patient population. Adequate proportions play an important role in the aesthetic aspect of the breast, therefore a proper analysis and planning must be done for surgeons to obtain better results. Hyman DM, et al. AKT Inhibition in Solid Tumors With AKT1 Mutations. Journal of Clinical Oncology 35, 2251-2259 (2017). To standardize measurements, first from a front view a horizontal line at the level of the nipples is drawn (Horizontal nipple plane), then a vertical line is drawn from the nipple to the inframammary fold (Lower breast pole length). From a lateral view a horizontal line is drawn at the breaking point where the breast starts from the chest wall (superior breast limit). The upper breast pole is described as the area between the superior breast limit and the horizontal nipple plane. The lower breast pole is described as the area between the nipple and the Inframammary Fold (IMF). The proportion of each breast pole was established by diving the length of each pole by the sum of the vertical distance, over the breast, between the superior limit and the inframammary fold at the level of the nipple, and then multiplied by 100 (LBPL/(LBPL + UBPL) * 100). Tfayli, A., Temraz, S., Abou Mrad, R. & Shamseddine, A. Breast cancer in low- and middle-income countries: an emerging and challenging epidemic. J. Oncol. 2010, 490631 (2010).Detected mutations were annotated and classified as driver and passenger somatic mutations using the method implemented in OncodriveMUT algorithm 76 and the Cancer Genome Interpreter ( https://www.cancergenomeinterpreter.org/home) framework, which allows to identify the most likely driver mutations of a tumor. The oncogenic classification: known and predicted mutation (in any neoplasia), were considered as driver alteration and taken into account for analysis. Structural 3D view of AKT1 mutations Gori, K. & Baez-Ortega A. sigfit: flexible Bayesian inference of mutational signatures. Preprint at bioRxiv https://doi.org/10.1101/372896 (2020).

Having big boobs can be a blessing and a curse — as one woman found out when she attempted to do a week without wearing a bra. Pitt, J. J. et al. Characterization of Nigerian breast cancer reveals prevalent homologous recombination deficiency and aggressive molecular features. Nat. Commun. 9, 4181 (2018). Introduce anal play with a Novice Plug, the perfect anal vibrator for newbies with a slim design, smooth silicone, and a remote control from up to 30 feet away." — A.W. This represents a challenge for Plastic Surgeons in Mexico because an increased SNN:N distance in the context of a shorter height in the population, puts our patients at risk of ptosis regardless of the age. Big breasts might seem like a blessing to some. However, one buxom influencer finds her cumbersome chest to be a massive burden, as she’s allegedly forced to wear multiple bras at once to work out, among other inconveniences. The blond bombshell showed off her apparently problematic mammaries in a series of TikTok videos with millions of views.

Roberts, S. A. et al. An APOBEC cytidine deaminase mutagenesis pattern is widespread in human cancers. Nat. Genet. 45, 970–976 (2013).

Comparing the values found in this study to the aesthetically ideal breast described by Malluci, we observe that our measurements fall far from what is considered ideal breast proportion [2] [7] ( Table 6). As mentioned previously this correlates with our findings in everyday practice, where we have detected an important prevalence of tuberous breasts.While comparing the measurements of our population with those published of other nations and ethnicities, we found differences and similarities. The Nipple Areola Complex diameter was similar to Saudi Arabia and Turkey, but statistically different from Asian and Caucasian patients [3] [4] ( Table 8). Johnson, W. E., Li, C. & Rabinovic, A. Adjusting batch effects in microarray expression data using empirical Bayes methods. Biostatistics 8, 118–127 (2007).

The female breast represents the center of femininity and constitutes one of the most important physical and psychological elements in a woman. It is characterized by a diverse anatomy that comprises different volumes, width, height, projection, composition, shape, and position in the chest wall. Rooney, M. S., Shukla, S. A., Wu, C. J., Getz, G. & Hacohen, N. Molecular and genetic properties of tumors associated with local immune cytolytic activity. Cell 160, 48–61 (2015).The third reason is a bit more of a fashion challenge, because I actually want to try and see what clothes I can wear with my boobs without a bra because I’ll be limited, especially in summer.” Figure 2. Breast anthropometric measurements. SN, sternal notch; IMF, inframammary fold; IND, internipple distance; and AD, areolar diameter.